Ankylosing Spondylitis

Ankylosing spondylitis (AS) is a form of arthritis that involves primarily the spine and joints of the extremities, such as the shoulders, hips and knees. It strikes young adults (usually men in their 30s), causing pain, stiffness, eye inflammation, and possible disability in severe cases. It makes hip, shoulders, ribs, back and neck stiff and sore and can cause a stiff, inflexible backbone.

AS is a member of the family of diseases that attack the spine called spondylarthropathies. The cause of AS is not known, but all of the spondylarthropathies share a common genetic marker, called HLA-B27, in most affected individuals. It has a strong familial tendency and a male predilection. It is more common in westerners, but has low incidence in Japenese and Negroid population.

Symptoms of Ankylosing Spondylitis

There is a preferential involvement of ligaments and tendons known as Enthesopathy. There are two basic affections-

1. Synovitis of diarthrodial or synovial joints

• Synovitis of the Sacro illiac joint in the back and the facet joints of veretebare causes destruction of articular cartilage and periarticular bone

• The costovertebral joints (Rib articulating with back bone) are commonly affected which causes reduced respiratory exc

• When other joints are affected the same changes occur

2. Inflammation of fibro-osseus junctions of syndesmotic joints

• This affects the intervertebral discs, SI joint ligaments, manubriosternal joint, pubic symphysis and the bony insertions of large tendons

These changes in the joint occur in three stages-

1. Inflammatory reaction with round cell infiltration, granulation tissue and destruction of bone.

2. Replacement of the granulation tissue with fibrous tissue

3. Ossification of the fibrous tissue leading to ankylosis of joints

6. Serum rheumatoid factor

Demonstration of abnormal amounts of serum rheumatoid factor by any method for which the result has been positive in <5% of normal control subjects.

Also, replica watches uk are now more realistic and similar to their genuine counterparts, so buyers do not feel that the replica watches sale are purely imitation. The fact that the rich and famous regularly utilize rolex replica uk to express their status has made replica pieces all the more popular. People see their favorite celebrity donning a certain watch, and all of a sudden they want one too. It is difficult to have what omega replica uk have, though, as they have exorbitant amounts of money to spend. Therefore, people can get as close as possible by purchasing a replica of the desired item. Patek Philippe Classic Square Automatic rolex replica sale are perfect, as a replica Patek Philippe Annual Calendar Men’s watches can be easily misconstrued as real, while other, larger items like cars cannot be.
Symptoms of Ankylosing Spondylitis

The usual symptoms start with low back pai